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RECEPTOR, ERBB-2
Descriptors Found:
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DeCS
Descriptor
English
:
Receptor, ErbB-2
Descriptor
Spanish
:
Receptor ErbB-2
Descriptor
Portuguese
:
Receptor ErbB-2
Synonyms
English
:
c-erbB-2 Protein
erbB-2 Proto-Oncogene Protein
erbB-2 Receptor Protein-Tyrosine Kinase
neu Proto-Oncogene Protein
HER-2 Proto-Oncogene Protein
Proto-Oncogene Protein p185(neu)
Proto-Oncogene Protein HER-2
Tree Number:
D08.811.913.696.620.682.725.400.009.400
D12.776.543.750.060.009.400
D12.776.543.750.750.400.074.400
D12.776.624.664.700.642
D23.050.301.264.035.596
D23.101.100.110.596
D23.101.140.642
Definition
English
:
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor
family
member.
See Related
English
:
Genes, erbB-2
History Note
English
:
2000(1995); use RECEPTOR, ERBB-2 (NM) 1985-1994
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
32062
Unique Identifier:
D018719
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS